This 26.5% difference was considered clinically significant. present but not disturbing), as reported daily by the patients, was significantly greater with cetirizine (56.2%) than placebo (29.7%). The mean percentage of study days when symptoms were absent or at the most mild (i.e. Compliance was checked and found to be less than 80% of the prescribed dosage in 2 cetirizine patients. Unchanged treatment of asthma was allowed and inhaled corticosteroids were continued in 3 placebo patients. Appropriate wash-out periods for previous medicines were observed. Rhinorrhea, sneezing, nasal obstruction and nasal and ocular pruritus were evaluated using symptom scores by patients on daily self-evaluation cards and by investigators who, in addition, made a global evaluation at the end of treatment. A total of 124 children of both sexes aged between 6 and 12 years with pollen-associated rhino-conjunctivitis were included in a multicentre double-blind study of parallel group design to compare the effects of cetirizine 10 mg daily, given as 5 mg morning and evening for 2 weeks, with those of placebo of identical appearance.
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